Selected publications:
Benjamin A. Juliar, Ian B. Stanaway, Fumika Sano, Hongxia Fu, Kelly Smith, Suzie J. Scales, Jamal El Saghir, Pavan K. Bhatraju, Sean Eddy, Matthias Kretzler, Ying Zheng, Jennifer L. Harder, Jonathan Himmelfarb, Benjamin S. Freedman. Interferon-γ induces combined pyroptotic angiopathy and APOL1 expression in human kidney disease. Cell Reports. 43:114310, 2024. PMID: 38838223.
Sienna R. Li, Ramila E. Gulieva, Nelly M. Cruz, Ivan G. Gomez, Hongxia Fu, Benjamin S. Freedman. Fluidic absorption drives cystogenesis in a human organoid-on-a-chip model of kidney disease. Nature Communications. 13:7918. 2022. PMID: 36564419.
Ariëns RA, Hunt BJ, Agbani EO, Ahnström J, Ahrends R, Alikhan R, Assinger A, Bagoly Z, Balduini A, Barbon E, Barrett CD, Batty P, Carneiro JDA, Chan WS, de Maat M, de Wit K, Denis C, Ellis MH, Eslick R, Fu H, Hayward CPM, Ho-Tin-Noé B, Klok FA, Kumar R, Leiderman K, Litvinov RI, Mackman N, McQuilten Z, Neal MD, Parker WAE, Preston RJS, Rayes J, Rezaie AR, Roberts LN, Rocca B, Shapiro S, Siegal DM, Sousa LP, Suzuki-Inoue K, Zafar T, Zhou J. Illustrated State-of-the-Art Capsules of the ISTH 2022 Congress. Res Pract Thromb Haemost. 6(5):e12747, 2022. PMID: 35814801.
Nelly M. Cruz, Raghava Reddy, José L. McFaline-Figueroa, Christine Tran, Hongxia Fu, Benjamin S. Freedman. Modelling ciliopathy phenotypes in human tissues derived from pluripotent stem cells with genetically ablated cilia. Nature Biomedical Engineering. 6: 463-475. PMID: 35478224. 2022.
Samuel Rayner*, Zackary Scholl*, Christain Mandrycky, Junmei Chen, Karina Lavalley, Peter Leary, William Altemeier, Conrad Liles, Dominic Chuang, José López, Hongxia Fu*, Ying Zheng*. Enthothelial-derived von Willebrand factor accelerates fibrin clotting within engineered microvessles. J. Thormb. Haemost. 20(7):1627-1637, 2022. PMID: 35343037.
Hongxia Fu, Yan Jiang, Wesley P. Wong, and Timothy A. Springer. Single-molecule imaging of von Willebrand factor reveals tension-dependent self-association. Blood. 138:2425, 2021.
Xiaodan Zhao, Shiwen Guo, Chen Lu, Jin Chen, Shimin Le, Hongxia Fu, Jie Yan. Single-molecule manipulation quantification of site-specific DNA binding. Current Opinion in Chemical Biology. 53:106-117, 2019.
Jiang Yan, Hongxia Fu, Timothy Springer, and Wesley Wong. Electrostatic steering enables flow-activated von Willebrand Factor to bind platelet glycoprotein, revealed by single-molecule stretching and imaging. Journal of Molecular Biology. 431:1380-1396, 2019.
Stefan M. Czerniecki, Nelly M. Cruz, Jennifer L. Harder, Rajasree Menon, James Annis, Edgar A. Otto, Ramila E. Gulieva, Laura V. Islas, Yong Kyun Kim, Linh M. Tran, Timothy J. Martins, Jeffery W. Pippin, Hongxia Fu, Matthias Kretzler, Stuart J. Shankland, Jonathan Himmelfarb, Randall T. Moon, Neal Paragas, Benjamin S. Freedman. High-throughput screening enhances kidney organoid differentiation from human pluripotent stem cells and enables automated multidimensional phenotyping. Cell Stem Cell. 22:929-940, 2018.
Yong Kyun Kim, Ido Refaeli, Craig R. Brooks, Peifeng Jing, Ramila E. Gulieva, Michael R. Hughes, Nelly M. Cruz, Yannan Liu, Angela J. Churchill, Hongxia Fu, Jeffrey W. Pippin, Lih Y. Lin, Stuart J. Shankland, A. Wayne Vogl, Kelly M. McNagny, Benjamin S. Freedman. Gene-Edited Human Kidney Organoids Reveal Mechanisms of Disease in Podocyte Development. Stem Cells. 35(12):2366-2378. 2017.
Nelly M. Cruz, Xuefen Song, Stefan M. Czerniecki, Ramila E. Gulieva, Angela J. Churchill, Yong Kyun Kim, Kosuke Winston, Marco A. Diaz, Hongxia Fu, Laura S. Finn, York Pei, Jonathan Himmelfarb, Benjamin S. Freedman. Organoid Cystogenesis Reveals a Critical Role of Microenvironment in Human Polycystic Kidney Disease. Nature Materials. 16:1112, 2017.
Hongxia Fu, Jiang Yan, Darren Yang, Friedrich Scheiflinger, Wesley Wong, and Timothy Springer. Flow-Induced Elongation of Von Willebrand Factor Procedes Tension-Dependent Activation. Nature Communications. 8:324, 2017.
Freedman, Craig Brooks, Albert Lam, Hongxia Fu, Ryuji Morizane, Vishesh Agrawal, Abdelaziz Saad, Michelle Li, Michael Hughes, Ryan van der Werff, Derek Peters, Junjie Lu, Anna Baccei, Andrew Siedlecki, M. Todd Valerius, Kiran Musunuru, Kelly McNagny, Theodore Steinman, Jing Zhou, Paul Lerou, and Joseph Bonventre. Modeling Kidney Disease with CRISPR-mutant Kidney Organoids Derived from Human Pluripotent Epiblast Spheroids. Nature Communications. 6:8715, 2015.
Hongxia Fu, Shimin Le, Kalappa Muniyappa, Jie Yan. Dynamics and Regulation of RecA Polymerization and De-Polymerization on Double-Stranded DNA. PLoS One. 8(6): e66712, 2013.
Hongxia Fu, Shimin Le, Hu Chen, Kalappa Muniyappa, and Jie Yan. Force and ATP Hydrolysis Dependent Regulation of RecA Nucleoprotein Filament by Single-stranded DNA Binding Protein. Nucleic Acids Research. 41(2): 924-932, 2013.
Xinghua Zhang, Hu Chen, Hongxia Fu, Patrick S. Doyle, and Jie Yan. Two Distinct Overstretched DNA Structures Revealed by Single-Molecule Thermodynamics Measurements. Proc Natl Acad Sci. 109: 8103-8108, 2012.
Hongxia Fu, Benjamin S. Freedman, ChweeTeck Lim, Rebecca Heald, and Jie Yan. Atomic Force Microscope Imaging of Chromatin Assembled in Xenopus laevis Egg Extract. Chromosoma, 120: 245-254, 2011.
Hu Chen, Hongxia Fu, Xiaoying Zhu, Peiwen Cong, F. Nakamura, and Jie Yan. Improved High-force Magnetic Tweezers for Stretching and Refolding of Proteins and Short DNA. Biophysical Journal. 100(2): 517-23, 2011.
Hongxia Fu, Hu Chen, Xinghua Zhang, Yuanyuan Qu, John F. Marko and Jie Yan. Transition Dynamics and Selection of the Distinct S-DNA and Strand Unpeeling Modes of Double Helix Overstretching. Nucleic Acids Research. 39(8): 3473-81, 2011.
Hongxia Fu, Hu Chen, John F. Marko, and Jie Yan. Two Distinct Overstretched DNA States. Nucleic Acid Research. 38(16):5594-5600, 2010. (Selected by Journal as a Featured Article of the Year.)
Mo, Q. Li, L. W. Y. Lui, B. Zheng, C. H. Kang, B. Nugraha, Z. Yue, R. R. Jia, Hongxia Fu, D. Choudhury, T. Arooz, Jie Yan, Chwee Teck Lim, S. Shen, C. H. Tan and H. Yu. Rapid Construction of Mechanically-Confined Multi-Cellular Structures Using Dendrimeric Intercellular Linker. Biomaterials. 31 (29): 7455-7467, 2010.
Hongxia Fu, Hu Chen, Jie Yan, Chwee Teck Lim. Salt Solution Effects on Overstretching Transitions of DNA Molecules. Journal of Computational and Theoretical Nanoscience. 7: 1272-1278, 2010.
Hongxia Fu, Hu Chen, Chan Ghee Koh and Chwee Teck Lim. Effects of Magnesium Salt Concentrations on B-DNA Overstretching Transition. European Physical Journal E. 29: 45-49, 2009.
Hu Chen, Hongxia Fu and Chan Ghee Koh, Sequence-Dependent Unpeeling Dynamics of Stretched DNA Double Helix. Journal of Computational and Theoretical Nanoscience. 5:1381-1386, 2008.
Chwee Teck Lim, E.H. Zhou, A. Li, S.R.K. Vedula and Hongxia Fu. Experimental Techniques for Single Cell and Single Molecule Biomechanics. Materials Science and Engineering C: Biomimetic & Supramolecular Systems. 8: 1278-1288, 2006.
Hongxia Fu, Chan Ghee Koh, and Hu Chen. Ionic Effects on Overstretching Transition of B-DNA. European Physical Journal E. 17: 231-235, 2005.